Acetate → 3-[5-Hydroxy-2-(4-hydroxy-phenyl)benzofuran-7-yl]-acrylic acid methyl ester

HRID 2325242Notes

Reaction equation

HRID 2325242 reaction equation
[Br:1][c:2]1[cH:3][c:4]([OH:18])[cH:5][c:6]2[cH:7][c:8](-[c:11]3[cH:12][cH:13][c:14]([OH:17])[cH:15][cH:16]3)[o:9][c:10]12.[C:19]([CH:20]=[CH2:21])(=[O:22])[O:23][CH3:24].[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH3:33][C:34]#[N:35].[ClH:25].[O-:37][C:38]([CH3:39])=[O:40].[O-:41][C:42]([CH3:43])=[O:44].[Pd+2:36]>>[c:2]1([CH:21]=[CH:20][C:19](=[O:22])[O:23][CH3:24])[cH:3][c:4]([OH:18])[cH:5][c:6]2[cH:7][c:8](-[c:11]3[cH:12][cH:13][c:14]([OH:17])[cH:15][cH:16]3)[o:9][c:10]12

Participants

8

Reactant 7

HCID 175Acetate2×HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 7294Methyl AcrylateHCID 8471TriethylamineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 102863527-Bromo-2-(4-hydroxy-phenyl)-benzofuran-5-ol

Product 1

HCID 688433923-[5-Hydroxy-2-(4-hydroxy-phenyl)benzofuran-7-yl]-acrylic acid methyl ester

Sources & evidence

ORD record
ord-f41d2eebacbc489cb76b0ecc84fdc90c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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