Hydrochloric Acid → N-(5-Chlorobenzo[d][1,3]dioxol-4-yl)-7-fluoro-5-((tetrahydro-2H-pyran-4-yl)oxy)quinazolin-4-amine
Reaction equation
[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:1][C:2]([CH3:3])([O-:4])[CH3:5].[Cl:15][c:16]1[cH:17][cH:18][c:19]2[c:20]([c:21]1[NH:22][c:23]1[n:24][cH:25][n:26][c:27]3[cH:28][c:29]([F:34])[cH:30][c:31]([F:33])[c:32]13)[O:35][CH2:36][O:37]2.[ClH:14].[K+:6].[OH2:38].[OH:7][CH:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1>>[O:7]([CH:8]1[CH2:9][CH2:10][O:11][CH2:12][CH2:13]1)[c:31]1[cH:30][c:29]([F:34])[cH:28][c:27]2[n:26][cH:25][n:24][c:23]([NH:22][c:21]3[c:16]([Cl:15])[cH:17][cH:18][c:19]4[c:20]3[O:35][CH2:36][O:37]4)[c:32]21Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-ed69662f55154386b78dd2b611467d18
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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