Chloride → ethyl(2RS,3RS)-2-((4-fluorophenyl)methyl)-3-hydroxy-3-(4-(trifluoromethyl)phenyl)propionate

HRID 2327052Notes

Reaction equation

HRID 2327052 reaction equation
[BH4-:1].[Cl-:29].[Cl-:31].[ClH:32].[F:3][c:4]1[cH:5][cH:6][c:7]([CH2:10][CH:11]([C:12](=[O:13])[O:14][CH2:15][CH3:16])[C:17]([c:18]2[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]2)=[O:28])[cH:8][cH:9]1.[Na+:2].[Zn+2:30]>>[F:3][c:4]1[cH:5][cH:6][c:7]([CH2:10][CH:11]([C:12](=[O:13])[O:14][CH2:15][CH3:16])[CH:17]([c:18]2[cH:19][cH:20][c:21]([C:24]([F:25])([F:26])[F:27])[cH:22][cH:23]2)[OH:28])[cH:8][cH:9]1

Participants

7

Reactant 6

HCID 312Chloride2×HCID 313Hydrochloric AcidHCID 923Sodium ionHCID 28123BorohydrideHCID 32051Zinc(2+)HCID 22261408Ethyl 2-((4-fluorophenyl)methyl)-3-oxo-3-(4-(trifluoromethyl)phenyl)propionate

Product 1

HCID 22261474ethyl(2RS,3RS)-2-((4-fluorophenyl)methyl)-3-hydroxy-3-(4-(trifluoromethyl)phenyl)propionate

Sources & evidence

ORD record
ord-461b6ccaf74b4610b5516d14eb27f708
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…