Hydrochloric Acid → 7'-(2-Fluoro-3-pyridinyl)-3'-(3-fluoropyrrolidin-1-yl)spiro[2,6-dihydro-1,4-oxazine-5,5'-chromeno[2,3-b]pyridine]-3-amine

HRID 2328263Notes

Reaction equation

HRID 2328263 reaction equation
[Br:8][c:9]1[cH:10][c:11]2[c:12]([n:13][cH:14]1)[O:15][c:16]1[cH:17][cH:18][c:19](-[c:29]3[c:30]([F:35])[n:31][cH:32][cH:33][cH:34]3)[cH:20][c:21]1[C:22]21[CH2:23][O:24][CH2:25][C:26]([NH2:28])=[N:27]1.[CH2:46]1[O:47][CH2:48][CH2:49][CH2:50]1.[CH3:37][Si:38]([N-:39][Si:40]([CH3:41])([CH3:42])[CH3:43])([CH3:44])[CH3:45].[ClH:7].[F:1][CH:2]1[CH2:3][NH:4][CH2:5][CH2:6]1.[Li+:36]>>[F:1][CH:2]1[CH2:3][N:4]([c:9]2[cH:10][c:11]3[c:12]([n:13][cH:14]2)[O:15][c:16]2[cH:17][cH:18][c:19](-[c:29]4[c:30]([F:35])[n:31][cH:32][cH:33][cH:34]4)[cH:20][c:21]2[C:22]32[CH2:23][O:24][CH2:25][C:26]([NH2:28])=[N:27]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 3280088Npc316347HCID 3744989Pyrrolidine, 3-fluoro-HCID 674369573-Bromo-7-(2-fluoropyridin-3-yl)-2',6'-dihydrospiro[chromeno[2,3-b]pyridine-5,3'-[1,4]oxazin]-5'-amine

Product 1

HCID 767946407'-(2-Fluoro-3-pyridinyl)-3'-(3-fluoropyrrolidin-1-yl)spiro[2,6-dihydro-1,4-oxazine-5,5'-chromeno[2,3-b]pyridine]-3-amine

Sources & evidence

ORD record
ord-50fb80ac630340e091b67e66e4025beb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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