Hydrogen Peroxide → 2,4-dimethoxy-5-(1-methyl-1H-indol-2-yl)benzaldehyde

HRID 2329003Notes

Reaction equation

HRID 2329003 reaction equation
[Br:16][c:17]1[c:18]([O:27][CH3:28])[cH:19][c:20]([O:25][CH3:26])[c:21]([CH:22]=[O:23])[cH:24]1.[C:11]([Li:12])([CH3:13])([CH3:14])[CH3:15].[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH3:1][n:2]1[cH:3][cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12.[Na+:30].[OH-:29].[OH:31][OH:32].[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[CH3:1][n:2]1[c:3](-[c:17]2[c:18]([O:27][CH3:28])[cH:19][c:20]([O:25][CH3:26])[c:21]([CH:22]=[O:23])[cH:24]2)[cH:4][c:5]2[cH:6][cH:7][cH:8][cH:9][c:10]12

Participants

10

Reactant 9

HCID 784Hydrogen PeroxideHCID 923Sodium ionHCID 961HydroxideHCID 8028TetrahydrofuranHCID 11776Triphenylphosphine2×HCID 117811-MethylindoleHCID 24290Palladium ChlorideHCID 6683465-Bromo-2,4-dimethoxybenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 219810062,4-dimethoxy-5-(1-methyl-1H-indol-2-yl)benzaldehyde

Sources & evidence

ORD record
ord-3162a3abbe174d65a6ff7415b91e2ec9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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