Water → 2-chloro-5-iodo-N-(6-methoxypyridin-3-yl)pyrimidin-4-amine

HRID 2331377Notes

Reaction equation

HRID 2331377 reaction equation
[CH:19]([N:20]([CH2:21][CH3:22])[CH:23]([CH3:24])[CH3:25])([CH3:26])[CH3:27].[Cl:1][c:2]1[n:3][cH:4][c:5]([I:9])[c:6]([Cl:8])[n:7]1.[Cu:35][I:36].[NH2:10][c:11]1[cH:12][cH:13][c:14]([O:17][CH3:18])[n:15][cH:16]1.[O:28]1[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1.[OH2:34]>>[Cl:1][c:2]1[n:3][cH:4][c:5]([I:9])[c:6]([NH:10][c:11]2[cH:12][cH:13][c:14]([O:17][CH3:18])[n:15][cH:16]2)[n:7]1

Participants

7

Reactant 6

HCID 962WaterHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 312751,4-DioxaneHCID 811216-Methoxy-3-pyridinylamineHCID 81531DiisopropylethylamineHCID 2634382,4-Dichloro-5-iodopyrimidine

Product 1

HCID 866470532-chloro-5-iodo-N-(6-methoxypyridin-3-yl)pyrimidin-4-amine

Sources & evidence

ORD record
ord-afbc73d853f341588c0fc3f6814e349a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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