Nitrogen → N-(4-(1-(4-methoxybenzyl)-3-(5-((4-methylpiperazin-1-yl)methyl)furan-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yloxy)-3-fluorophenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Reaction equation
[Br:70][c:71]1[cH:72][c:73]([CH2:74][N:75]2[CH2:76][CH2:77][N:78]([CH3:79])[CH2:80][CH2:81]2)[o:82][c:83]1[Sn:84]([CH2:85][CH2:86][CH2:87][CH3:88])([CH2:89][CH2:90][CH2:91][CH3:92])[CH2:93][CH2:94][CH2:95][CH3:96].[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][n:8]2[n:9][c:10]([I:41])[c:11]3[c:12]2[n:13][cH:14][cH:15][c:16]3[O:17][c:18]2[c:19]([F:40])[cH:20][c:21]([N:24]([C:25](=[O:26])[C:27]3([C:30](=[O:31])[NH2:32])[CH2:28][CH2:29]3)[c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[cH:22][cH:23]2)[cH:42][cH:43]1.[CH3:44][N:45]1[CH2:46][CH2:47][N:48]([CH2:51][c:52]2[o:53][cH:54][c:55]([Sn:57]([CH2:58][CH2:59][CH2:60][CH3:61])([CH2:62][CH2:63][CH2:64][CH3:65])[CH2:66][CH2:67][CH2:68][CH3:69])[cH:56]2)[CH2:49][CH2:50]1.[N:97]#[N:98].[O:99]1[CH2:100][CH2:101][O:102][CH2:103][CH2:104]1.[Pd:105]([Cl:106])[Cl:107].[c:108]1([P:109]([c:110]2[cH:111][cH:112][cH:113][cH:114][cH:115]2)[c:116]2[cH:117][cH:118][cH:119][cH:120][cH:121]2)[cH:122][cH:123][cH:124][cH:125][cH:126]1.[c:127]1([P:128]([c:129]2[cH:130][cH:131][cH:132][cH:133][cH:134]2)[c:135]2[cH:136][cH:137][cH:138][cH:139][cH:140]2)[cH:141][cH:142][cH:143][cH:144][cH:145]1>>[CH3:1][O:2][c:3]1[cH:4][cH:5][c:6]([CH2:7][n:8]2[n:9][c:10](-[c:55]3[cH:54][o:53][c:52]([CH2:51][N:48]4[CH2:47][CH2:46][N:45]([CH3:44])[CH2:50][CH2:49]4)[cH:56]3)[c:11]3[c:12]2[n:13][cH:14][cH:15][c:16]3[O:17][c:18]2[c:19]([F:40])[cH:20][c:21]([N:24]([C:25](=[O:26])[C:27]3([C:30](=[O:31])[NH2:32])[CH2:28][CH2:29]3)[c:33]3[cH:34][cH:35][c:36]([F:39])[cH:37][cH:38]3)[cH:22][cH:23]2)[cH:42][cH:43]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-704c93a289da4b7aaa1ee0aeec52ef7c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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