Dimethylformamide → Pyridine-3-carboxamide, 4-chloro-N-(2,4-difluorophenyl)-

HRID 2333818Notes

Reaction equation

HRID 2333818 reaction equation
[Br:27][P+:28]([N:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1)([N:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1)[N:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[CH:44]([N:45]([CH:46]([CH3:47])[CH3:48])[CH2:49][CH3:50])([CH3:51])[CH3:52].[Cl:1][c:2]1[cH:3][cH:4][n:5][cH:6][c:7]1[C:8](=[O:9])[OH:10].[Cl:53][CH2:54][Cl:55].[F:11][c:12]1[c:13]([NH2:14])[cH:15][cH:16][c:17]([F:19])[cH:18]1.[O:56]=[CH:57][N:58]([CH3:59])[CH3:60].[P-:20]([F:21])([F:22])([F:23])([F:24])([F:25])[F:26]>>[Cl:1][c:2]1[cH:3][cH:4][n:5][cH:6][c:7]1[C:8](=[O:10])[NH:14][c:13]1[c:12]([F:11])[cH:18][c:17]([F:19])[cH:16][cH:15]1

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 6344DichloromethaneHCID 97092,4-DifluoroanilineHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 8182294-Chloronicotinic acidHCID 2733180Bromotripyrrolidin-1-ylphosphonium

Product 1

HCID 587732Pyridine-3-carboxamide, 4-chloro-N-(2,4-difluorophenyl)-

Sources & evidence

ORD record
ord-87f8c436a8cf425689a28ab0506c8894
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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