Tetrahydrofuran → 4-Chloro-6-trimethylsilanylethynyl-thieno[3,2-d]pyrimidine

HRID 2333850Notes

Reaction equation

HRID 2333850 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[n:5][cH:6][n:7][c:8]([Cl:11])[c:9]2[s:10]1.[CH2:18]1[O:19][CH2:20][CH2:21][CH2:22]1.[CH3:12][Si:13]([CH3:14])([CH3:15])[C:16]#[CH:17].[Cu:23][I:24]>>[c:2]1([C:17]#[C:16][Si:13]([CH3:12])([CH3:14])[CH3:15])[cH:3][c:4]2[n:5][cH:6][n:7][c:8]([Cl:11])[c:9]2[s:10]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 183827966-Bromo-4-chlorothieno(3,2-d)pyrimidine

Product 1

HCID 858432224-Chloro-6-trimethylsilanylethynyl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-65925925b1ee44a581c09e33a990fc39
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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