Hydrochloric Acid → 6-(Hydroxymethyl)-2H-1,4-benzoxazin-3(4H)-one

HRID 2335257Notes

Reaction equation

HRID 2335257 reaction equation
[CH3:16][CH:17]([CH2:18][AlH:19][CH2:20][CH:21]([CH3:22])[CH3:23])[CH3:24].[ClH:25].[O:1]=[C:2]1[CH2:3][O:4][c:5]2[c:6]([cH:8][c:9]([C:12](=[O:13])[O:14][CH3:15])[cH:10][cH:11]2)[NH:7]1.[O:26]1[CH2:27][CH2:28][CH2:29][CH2:30]1>>[O:1]=[C:2]1[CH2:3][O:4][c:5]2[c:6]([cH:8][c:9]([CH2:12][OH:13])[cH:10][cH:11]2)[NH:7]1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 14487Diisobutylaluminum hydrideHCID 2974054Methyl 3-oxo-3,4-dihydro-2H-1,4-benzoxazine-6-carboxylate

Product 1

HCID 184524436-(Hydroxymethyl)-2H-1,4-benzoxazin-3(4H)-one

Sources & evidence

ORD record
ord-0abfe8e58e1f4c6a8388f1e6384deeb9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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