1,2-Dichloroethane → 1-[4-[4-[5-Amino-6-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyrazin-2-yl]pyrazol-1-yl]piperidin-1-yl]-2-(dimethylamino)ethanone
Reaction equation
[Br:59][c:60]1[n:61][c:62]([O:63][CH:64]([c:65]2[c:66]([Cl:67])[cH:68][cH:69][c:70]([F:71])[c:72]2[Cl:73])[CH3:74])[c:75]([NH2:76])[n:77][cH:78]1.[CH2:48]([Cl:49])[CH2:50][Cl:51].[CH3:31][N:32]([CH3:33])[CH2:34][C:35](=[O:36])[OH:37].[CH3:52][CH2:53][N:54]([CH2:55][CH3:56])[CH2:57][CH3:58].[Cl:1][c:2]1[c:3]([CH:10]([CH3:11])[O:12][c:13]2[c:14]([NH2:30])[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][n:22]([CH:24]4[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]4)[cH:23]3)[n:18]2)[c:4]([Cl:9])[cH:5][cH:6][c:7]1[F:8].[O:79]=[CH:80][N:81]([CH3:82])[CH3:83].[OH:38][n:39]1[c:40]2[c:41]([cH:42][cH:43][cH:44][cH:45]2)[n:46][n:47]1>>[Cl:1][c:2]1[c:3]([CH:10]([CH3:11])[O:12][c:13]2[c:14]([NH2:30])[n:15][cH:16][c:17](-[c:19]3[cH:20][n:21][n:22]([CH:24]4[CH2:25][CH2:26][N:27]([C:35]([CH2:34][N:32]([CH3:31])[CH3:33])=[O:36])[CH2:28][CH2:29]4)[cH:23]3)[n:18]2)[c:4]([Cl:9])[cH:5][cH:6][c:7]1[F:8]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-7c7f95ba68a2472a81f25f208a9f2a35
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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