Formamide → p-Cyanobenzamide

HRID 2340746Notes

Reaction equation

HRID 2340746 reaction equation
[CH3:63][N:64]1[CH2:65][CH2:66][CH2:67][C:68]1=[O:69].[CH:10](=[O:11])[NH2:12].[CH:25]1([P:26]([CH:27]2[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]2)[CH:33]2[CH2:34][CH2:35][CH2:36][CH2:37][CH2:38]2)[CH2:39][CH2:40][CH2:41][CH2:42][CH2:43]1.[CH:44]1([P:45]([CH:46]2[CH2:47][CH2:48][CH2:49][CH2:50][CH2:51]2)[CH:52]2[CH2:53][CH2:54][CH2:55][CH2:56][CH2:57]2)[CH2:58][CH2:59][CH2:60][CH2:61][CH2:62]1.[Cl:1][c:2]1[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1.[N:13]1([c:14]2[cH:15][cH:16][n:17][cH:18][cH:19]2)[CH2:20][CH2:21][CH2:22][CH2:23]1.[Pd:24]>>[c:2]1([C:10](=[O:11])[NH2:12])[cH:3][cH:4][c:5]([C:6]#[N:7])[cH:8][cH:9]1

Participants

7

Reactant 6

HCID 713FormamideHCID 121634-ChlorobenzonitrileHCID 13387N-methyl-2-pyrrolidoneHCID 23938PalladiumHCID 755674-PyrrolidinopyridineHCID 75806Tricyclohexylphosphine2×

Product 1

HCID 76427p-Cyanobenzamide

Sources & evidence

ORD record
ord-a063213dfa9f46f0bb94d9b5a786f3fe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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