Tetrahydrofuran → Tert-butyl 3-[1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxylate

HRID 2342812Notes

Reaction equation

HRID 2342812 reaction equation
[CH2:32]1[O:33][CH2:34][CH2:35][CH2:36]1.[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][O:6][CH3:7].[Cl:9][c:10]1[c:11]([F:31])[c:12]([C:13](=[O:14])[CH:15]2[CH2:16][N:17]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19][CH2:20]2)[cH:28][cH:29][cH:30]1.[Mg:8]>>[CH2:2]([CH2:3][CH2:4][CH2:5][O:6][CH3:7])[C:13]([c:12]1[c:11]([F:31])[c:10]([Cl:9])[cH:30][cH:29][cH:28]1)([OH:14])[CH:15]1[CH2:16][N:17]([C:21](=[O:22])[O:23][C:24]([CH3:25])([CH3:26])[CH3:27])[CH2:18][CH2:19][CH2:20]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 873631-Chloro-4-methoxybutaneHCID 5462224MagnesiumHCID 57449673Tert-butyl 3-(3-chloro-2-fluorobenzoyl)piperidine-1-carboxylate

Product 1

HCID 72283032Tert-butyl 3-[1-(3-chloro-2-fluorophenyl)-1-hydroxy-5-methoxypentyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-de49fca1bbfa40b6b21044e5ab6d7f1e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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