Tetrahydrofuran → 1-(6-Chloropyridazin-3-yl)-1-(2,6-difluorophenyl)-4-(trimethylsilyl)but-3-yn-2-one
Reaction equation
[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:18][Si:19]([N-:20][Si:21]([CH3:22])([CH3:23])[CH3:24])([CH3:25])[CH3:26].[CH3:27][Si:28]([C:29]#[C:30][C:31](=[O:32])[O:33][CH2:34][CH3:35])([CH3:36])[CH3:37].[Cl:1][c:2]1[n:3][n:4][c:5]([CH2:8][c:9]2[c:10]([F:16])[cH:11][cH:12][cH:13][c:14]2[F:15])[cH:6][cH:7]1.[Li+:17]>>[Cl:1][c:2]1[n:3][n:4][c:5]([CH:8]([c:9]2[c:10]([F:16])[cH:11][cH:12][cH:13][c:14]2[F:15])[C:31]([C:30]#[C:29][Si:28]([CH3:27])([CH3:36])[CH3:37])=[O:32])[cH:6][cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-77d503ec9c8243669549e633a69467e9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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