Tetrahydrofuran → 7'-bromospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

HRID 2345594Notes

Reaction equation

HRID 2345594 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[NH:9][C:8](=[O:11])[C:7]2([CH2:12][OH:13])[c:14]1[cH:15][c:16]2[c:17]([cH:21][c:22]1[OH:23])[O:18][CH2:19][O:20]2.[CH2:24]([P:25]([CH2:26][CH2:27][CH2:28][CH3:29])[CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH3:36].[N:37]([C:38]([O:39][C:40]([CH3:41])([CH3:42])[CH3:43])=[O:44])=[N:45][C:46]([O:47][C:48]([CH3:49])([CH3:50])[CH3:51])=[O:52].[O:53]1[CH2:54][CH2:55][CH2:56][CH2:57]1>>[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[c:10]1[NH:9][C:8](=[O:11])[C:7]21[CH2:12][O:13][c:22]2[c:14]1[cH:15][c:16]1[c:17]([cH:21]2)[O:18][CH2:19][O:20]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 97268Di-tert-butyl azodicarboxylateHCID 685969097-bromo-3-(6-hydroxy-1,3-benzodioxol-5-yl)-3-(hydroxymethyl)-1,3-dihydro-2H-indol-2-one

Product 1

HCID 593525017'-bromospiro[furo[2,3-f][1,3]benzodioxole-7,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-9b59c03c889d436bb3d98217ad0b3ffa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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