Tetrahydrofuran → 3-(2-Fluoro-4-iodophenyl)-1-(1-(2-(tert-butyldimethylsilyloxy)ethyl)cyclopropylsulfonyl)-4-fluoro-8-methyl-1H-imidazo[4,5-g]quinazolin-2(3H)-one
Reaction equation
[C:35]([CH3:36])([CH3:37])([CH3:38])[Si:39]([O:40][CH2:41][CH2:42][C:43]1([S:46](=[O:47])(=[O:48])[Cl:49])[CH2:44][CH2:45]1)([CH3:50])[CH3:51].[CH2:52]1[O:53][CH2:54][CH2:55][CH2:56]1.[CH3:26][Si:27]([N-:28][Si:29]([CH3:30])([CH3:31])[CH3:32])([CH3:33])[CH3:34].[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:24])[nH:11][c:12]3[cH:13][c:14]4[c:15]([CH3:23])[n:16][cH:17][n:18][c:19]4[c:20]([F:22])[c:21]23)[cH:4][cH:5][c:6]([I:8])[cH:7]1.[Li+:25]>>[F:1][c:2]1[c:3](-[n:9]2[c:10](=[O:24])[n:11]([S:46]([C:43]3([CH2:42][CH2:41][O:40][Si:39]([C:35]([CH3:36])([CH3:37])[CH3:38])([CH3:50])[CH3:51])[CH2:44][CH2:45]3)(=[O:47])=[O:48])[c:12]3[cH:13][c:14]4[c:15]([CH3:23])[n:16][cH:17][n:18][c:19]4[c:20]([F:22])[c:21]23)[cH:4][cH:5][c:6]([I:8])[cH:7]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-c2283230d084452b96829bb66d808686
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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