4,7-Dichloroquinoline → HCID 9947937, compound

HRID 234681Notes

Reaction equation

HRID 234681 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[NH2:13][CH2:14][CH2:15][N:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>C(#N)C>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:13][CH2:14][CH2:15][N:16]3[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]3)=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

4

Reactant 2

HCID 68664,7-DichloroquinolineHCID 33944N-(2-Aminoethyl)piperidine

Product 1

HCID 9947937HCID 9947937, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

3.57 g of base from 3.96 g of 4,7-dichloroquinoline and 4.8 g of 1-(2-aminoethyl)-piperidine (reaction duration, 5 hours at 140° C.); yellowish crystals from acetonitrile, m.p.: 148°-151° C.

Sources & evidence

ORD record
ord-ba5f98369f4f45d9a305cc64cc876d1e
Source dataset
uspto-grants-1997_01
Patent number
US05596002

Reaction notes

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