Hydrochloric Acid → HCID 54081486, compound

HRID 234683Notes

Reaction equation

HRID 234683 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([Cl:12])=[CH:9][CH:10]=2)[N:5]=[CH:4][CH:3]=1.[CH2:13]([N:15]([CH2:22][CH3:23])[CH:16]1[CH2:20][CH2:19][CH2:18][CH:17]1[NH2:21])[CH3:14].Cl>C(O)(C)C>[Cl:12][C:8]1[CH:7]=[C:6]2[C:11]([C:2]([NH:21][CH:17]3[CH2:18][CH2:19][CH2:20][CH:16]3[N:15]([CH2:22][CH3:23])[CH2:13][CH3:14])=[CH:3][CH:4]=[N:5]2)=[CH:10][CH:9]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 68664,7-DichloroquinolineHCID 16791461HCID 16791461, compound

Product 1

HCID 54081486HCID 54081486, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

8.16 g of base from 16 g of 4,7-dichloroquinoline and 12.7 g of 2-(diethylamino)cyclopentylamine (16 hours reaction duration at 140° C.). By addition of isopropanolic hydrochloric acid to a solution of the diamine in isopropanol were precipitated 7.84 g of dihydrochloride; colourless crystals from acetonitrile/ethanol, m.p.: 186°-190° C.

Workup

  1. customwere precipitated 7.84 g of dihydrochloride

Sources & evidence

ORD record
ord-619fb4de75e2491f96fb22b9ad71b2ef
Source dataset
uspto-grants-1997_01
Patent number
US05596002

Reaction notes

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