Hydrochloric Acid → N-(4-chloro-2-fluorophenyl)-6-methoxy-7-[2-(pyrrolidin-1-yl)ethoxy]quinazolin-4-amine
Reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([OH:19])[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1.[Cl:30][CH2:31][CH2:32][N:33]1[CH2:34][CH2:35][CH2:36][CH2:37]1.[ClH:29].[K+:27].[K+:28].[O:38]=[CH:39][N:40]([CH3:41])[CH3:42]>>[Cl:1][c:2]1[cH:3][c:4]([F:22])[c:5]([NH:6][c:7]2[n:8][cH:9][n:10][c:11]3[cH:12][c:13]([O:19][CH2:31][CH2:32][N:33]4[CH2:34][CH2:35][CH2:36][CH2:37]4)[c:14]([O:17][CH3:18])[cH:15][c:16]23)[cH:20][cH:21]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-43de2696027c4a44990423705309ef8c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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