Ethyl Acrylate → HCID 52192718, compound

HRID 2350849Notes

Reaction equation

HRID 2350849 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:13]([O:17][CH2:18][CH3:19])(=[O:16])[CH:14]=[CH2:15]>C(OCC)C>[CH2:18]([O:17][C:13](=[O:16])[CH2:14][CH2:15][N:10]1[CH2:9][CH2:8][CH:7]([C:1]2[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=2)[CH2:12][CH2:11]1)[CH3:19]

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 698734-Phenylpiperidine

Product 1

HCID 52192718HCID 52192718, compoundYield 95%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

25.0 g of 4-phenylpiperidine (0.15 mol) are placed in 50 ml of diethyl ether and, while stirring, 15.1 g of ethyl acrylate are gradually added thereto. With a slight increase in temperature, a clear solution forms. After standing overnight at room temperature, the ether is distilled off. The oil remaining behind is the crude 3-(4-phenylpiperidino)-propionic acid ethyl ester (yield approx. 95%).

Workup

  1. temperatureWith a slight increase in temperature
  2. distillationthe ether is distilled off

Sources & evidence

ORD record
ord-ac6ecc2312df491dad7a40c2ce0c4a69
Source dataset
uspto-grants-1989_10
Patent number
US04871720

Reaction notes

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