Hydrochloric Acid → HCID 15671150, compound

HRID 2351522Notes

Reaction equation

HRID 2351522 reaction equation
N[C:2]1[CH:23]=[CH:22][C:5]([O:6][CH2:7][C:8]2([CH3:21])[CH2:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][C:12]([CH3:20])=[CH:13][C:14]=3[CH3:19])[O:9]2)=[CH:4][CH:3]=1.[ClH:24].N([O-])=O.[Na+].[C:29]([O:33][CH2:34][CH3:35])(=[O:32])[CH:30]=[CH2:31]>O.CC(C)=O>[Cl:24][CH:30]([CH2:31][C:2]1[CH:23]=[CH:22][C:5]([O:6][CH2:7][C:8]2([CH3:21])[CH2:17][C:16](=[O:18])[C:15]3[C:10](=[CH:11][C:12]([CH3:20])=[CH:13][C:14]=3[CH3:19])[O:9]2)=[CH:4][CH:3]=1)[C:29]([O:33][CH2:34][CH3:35])=[O:32]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 15671146HCID 15671146, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15671150HCID 15671150, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A procedure similar to that described in Preparation 5 was repeated, except that 1.8 g of 2-(4-aminophenoxymethyl)-2,5,7-trimethyl-4-oxochroman (prepared as described in Preparation 28), 2 ml of concentrated aqueous hydrochloric acid, 520 mg of sodium nitrite, 6 ml of ethyl acrylate, 83 mg of cuprous oxide, 20 ml of acetone and 1 ml of water were reacted, to afford 1.52 g of the title compound as a pale yellow oil.

Workup

  1. customA procedure similar to that described in Preparation 5
  2. customwere reacted

Sources & evidence

ORD record
ord-59b7bc2662b04c83a068ff227872390e
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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