Hydrochloric Acid → HCID 15671162, compound

HRID 2351527Notes

Reaction equation

HRID 2351527 reaction equation
[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[Cl:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22](N)=[CH:21][CH:20]=1)([CH3:16])[CH2:9][C:8]2=[O:26])(=[O:3])[CH3:2].[ClH:27].N([O-])=O.[Na+].[C:32]([O:36][CH2:37][CH3:38])(=[O:35])[CH:33]=[CH2:34]>O.CC(C)=O>[C:1]([O:4][C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][C:14]=1[Cl:15])[O:11][C:10]([CH2:17][O:18][C:19]1[CH:24]=[CH:23][C:22]([CH2:34][CH:33]([Cl:27])[C:32]([O:36][CH2:37][CH3:38])=[O:35])=[CH:21][CH:20]=1)([CH3:16])[CH2:9][C:8]2=[O:26])(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 15671161HCID 15671161, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15671162HCID 15671162, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A procedure similar to that described in Preparation 5 was repeated, except that 1.44 g of 6-acetoxy-2-(4-aminophenoxymethyl)-7-chloro-2-methyl-4-oxochroman (prepared as described in Preparation 36), 1.8 ml of concentrated aqueous hydrochloric acid, 330 mg of sodium nitrite, 18 ml of acetone, 3.7 ml of ethyl acrylate, 330 mg of cuprous oxide and 3 ml of water were reacted, to afford 600 mg of the title compound as a pale yellow oil.

Workup

  1. customA procedure similar to that described in Preparation 5
  2. customwere reacted

Sources & evidence

ORD record
ord-91626c5a2baf49e19954b33698cb11d8
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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