Hydrochloric Acid → HCID 15671143, compound

HRID 2351530Notes

Reaction equation

HRID 2351530 reaction equation
[C:1]([O:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH2:9][CH2:10][C:11]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22](N)=[CH:21][CH:20]=3)([CH3:16])[O:12]2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2].N([O-])=O.[Na+].[ClH:30].[C:31]([O:35][CH2:36][CH3:37])(=[O:34])[CH:32]=[CH2:33]>O.CC(C)=O>[C:1]([O:4][C:5]1[C:14]([CH3:15])=[C:13]2[C:8]([CH2:9][CH2:10][C:11]([CH2:17][O:18][C:19]3[CH:24]=[CH:23][C:22]([CH2:33][CH:32]([Cl:30])[C:31]([O:35][CH2:36][CH3:37])=[O:34])=[CH:21][CH:20]=3)([CH3:16])[O:12]2)=[CH:7][CH:6]=1)(=[O:3])[CH3:2]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 8821Ethyl AcrylateHCID 15671139HCID 15671139, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 15671143HCID 15671143, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 962WaterSolvent

Procedure

A procedure similar to that described in Preparation 5 was repeated, except that 1.3 g of 7-acetoxy-2-(4-aminophenoxymethyl)-2,8-dimethylchroman (prepared as described in Preparation 40), 340 mg of sodium nitrite, 1.3 ml of concentrated aqueous hydrochloric acid, 4 ml of ethyl acrylate, 60 mg of cuprous oxide, 10 ml of acetone and 0.5 ml of water were reacted, to afford 1.0 g of the title compound as a pale yellow oil.

Workup

  1. customA procedure similar to that described in Preparation 5
  2. customwere reacted

Sources & evidence

ORD record
ord-326115a5786f45829f87c13e37073b87
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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