反应详情

A 26.7 g. portion of 5-chloromethylpyrimidine was dissolved in 25 ml. of dimethylformamide, and 9.4 g. of 2,4-difluoroaniline was added, followed by 6.1 g. of sodium bicarbonate. The mixture was stirred for several days with gentle heating. It was then diluted with water and extracted with ethyl acetate. The organic layer was washed with water, dried over magnesium sulfate, and evaporated under vacuum to obtain 13.75 g. of oil. The oil was dissolved in dichloromethane and purified over silica gel, eluting with dichloromethane, to obtain 4.9 g. of the desired intermediate product.

1. extractionextracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materialdried over magnesium sulfate
4. customevaporated under vacuum
5. customto obtain 13.75 g
6. custompurified over silica gel
7. washeluting with dichloromethane
8. customto obtain 4.9 g