Methyl iodide → HCID 13712494, compound

HRID 2352223Notes

Reaction equation

HRID 2352223 reaction equation
[OH:1][C:2]1[CH:15]=[C:14]2[C:5]([NH:6][C:7]3[C:12]([S:13]2)=[CH:11][CH:10]=[CH:9][CH:8]=3)=[C:4]2[CH:16]=[CH:17][CH:18]=[CH:19][C:3]=12.CI.[C:22](=O)([O-])[O-].[K+].[K+]>CN(C)C=O.C(OCC)(=O)C>[CH3:22][O:1][C:2]1[CH:15]=[C:14]2[C:5]([NH:6][C:7]3[C:12]([S:13]2)=[CH:11][CH:10]=[CH:9][CH:8]=3)=[C:4]2[CH:16]=[CH:17][CH:18]=[CH:19][C:3]=12

Participants

6

Reactant 3

HCID 6328Methyl iodide2×HCID 11430Potassium Carbonate2×HCID 137124785-hydroxy-12H-benzo[a]phenothiazine

Product 1

HCID 13712494HCID 13712494, compoundYield 47.7%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 5-hydroxy-12H-benzo[a]phenothiazine (2.65 g) and methyl iodide (2.5 ml) in DMF (dimethylformamide) (10 ml) there was added powdered potassium carbonate (2.0 g). The mixture was stirred at room temperature and after 15 minutes, another addition of potassium carbonate (2.0 g) and methyl iodide (2.0 ml) was done. The mixture was stirred for a further 20 minutes, then it was diluted with ethyl acetate (100 ml and washed with water (60 ml) twice, dried and evaporated down. The residue was triturated with ether to afford solid crude product which was filtered (1.7 g). This crude product was chromatographed on a column of silica gel, eluting with dichloromethane to afford pure title compound (1.33 g), m.p. 168°-170° C.

Workup

  1. stirringThe mixture was stirred for a further 20 minutes
  2. washwashed with water (60 ml) twice
  3. customdried
  4. customevaporated down
  5. customThe residue was triturated with ether
  6. customto afford solid crude product which
  7. filtrationwas filtered (1.7 g)
  8. customThis crude product was chromatographed on a column of silica gel
  9. washeluting with dichloromethane

Sources & evidence

ORD record
ord-0483b04b9f7b409fb1e395c451a4f57c
Source dataset
uspto-grants-1989_10
Patent number
US04876246

Reaction notes

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