Hydrochloric Acid → HCID 57931332, compound

HRID 2353436Notes

Reaction equation

HRID 2353436 reaction equation
[CH3:1][N:2]1[CH:6]2[CH2:7][N:8](C(OC(C)(C)C)=O)[CH2:9][CH:5]2[N:4]=[C:3]1[C:17]([F:20])([F:19])[F:18].Cl>CO.C(OCC)(=O)C>[CH3:1][N:2]1[C:6]2[CH2:7][NH:8][CH2:9][C:5]=2[N:4]=[C:3]1[C:17]([F:19])([F:18])[F:20]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86635441HCID 86635441, compound

Product 1

HCID 57931332HCID 57931332, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

To the product from Step A in 2 mL of methanol was added 2 mL of saturated hydrochloric acid in ethyl acetate. After stirring for 2 h the reaction was concentrated in vacuo and the residue purified by preparative thin layer chromatography using an Analtech® 1500 micron plate (20% methanol/ethyl acetate, 2% ammonium hydroxide) to give the title compound as a white solid. LC/MS 192.2 (M+1).

Workup

  1. concentrationwas concentrated in vacuo
  2. customthe residue purified by preparative thin layer chromatography

Sources & evidence

ORD record
ord-9fe22546786b43e48485437abf101c34
Source dataset
uspto-grants-2010_07
Patent number
US07750034B2

Reaction notes

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