Triethylamine → (1-methyl-1H-imidazol-2-yl)methyl Methanesulfonate

HRID 2353473Notes

Reaction equation

HRID 2353473 reaction equation
[CH3:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[CH2:7][OH:8].C(N(CC)CC)C.[CH3:16][S:17](Cl)(=[O:19])=[O:18]>C1COCC1>[CH3:16][S:17]([O:8][CH2:7][C:3]1[N:2]([CH3:1])[CH:6]=[CH:5][N:4]=1)(=[O:19])=[O:18]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 573612(1-methyl-1H-imidazol-2-yl)methanol

Product 1

HCID 44627230(1-methyl-1H-imidazol-2-yl)methyl Methanesulfonate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of (1-methyl-1H-imidazol-2-yl)-methanol (Bionet Research, 66 mg, 0.59 mmol), triethylamine (0.25 mL, 0.89 mmol), and methanesulfonyl chloride (69 μL, 0.89 mmol) in 5 mL THF were processed as described in Example 1C to give the crude material which was used directly in the next reaction.

Sources & evidence

ORD record
ord-c1f77063eb134b749dec1fb9dce41dc6
Source dataset
uspto-grants-2010_07
Patent number
US07750039B2

Reaction notes

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