2-(Methylamino)ethanol → HCID 68707716, compound

HRID 2353696Notes

Reaction equation

[CH3:1][S:2]([CH2:5][C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)[N:9]=[C:8]([C:18]2[CH:23]=[CH:22][C:21]([NH:24][C:25](=[O:33])OC3C=CC=CC=3)=[CH:20][CH:19]=2)[N:7]=1)(=[O:4])=[O:3].C(N(CC)CC)C.[CH3:41][NH:42][CH2:43][CH2:44][OH:45]>CN1C(=O)CCC1>[OH:45][CH2:44][CH2:43][N:42]([CH3:41])[C:25]([NH:24][C:21]1[CH:20]=[CH:19][C:18]([C:8]2[N:7]=[C:6]([CH2:5][S:2]([CH3:1])(=[O:4])=[O:3])[CH:11]=[C:10]([N:12]3[CH2:17][CH2:16][O:15][CH2:14][CH2:13]3)[N:9]=2)=[CH:23][CH:22]=1)=[O:33]

Participants

Conditions

Temperature: 70 °C

Procedure

A solution of phenyl N-[4-[4-(methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidin-2-yl]phenyl]carbamate (94 mg, 2 mmol) and triethylamine (0.09 mL, 9.2 mmol) in NMP (1 mL) was added to 2-methylaminoethanol (10 mmol). The mixture was heated at 70° C. for 2 hours and the reaction purified by prep HPLC, to give the desired compound.

Workup

customthe reaction purified by prep HPLC

Sources & evidence

ORD record: ord-b9c3c48258bf4089a9ee445ad1fa20ff
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07750003B2

Reaction notes

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