反应详情

温度

50 °C

A suspension of 2-(4-chloro-phenyl)-N-ethyl-N-piperidin-4-yl-acetamide (Example A10., 3.37 g, 12.0 mmol), NaHCO3 (5.4 g, 64 mmol), NaI (1.2 g, 8 mmol) and 1-(2-chloro-ethyl)-3-(2,6-dimethyl-pyridin-4-yl)-urea (Example D1, 1.82 g 8 mmol) in THF (40 mL) is stirred at 50° C. for 27 days. The mixture is quenched with Na2CO3 (150 mL) and extracted with CH2Cl2 (3×100 mL). The organic extracts are washed with sat. aq. Na2CO3 (70 mL), dried (Na2SO4), filtered and evaporated. The residue is purified by MPLC to provide the title compound.

1. customThe mixture is quenched with Na2CO3 (150 mL)
2. extractionextracted with CH2Cl2 (3×100 mL)
3. washThe organic extracts are washed with sat. aq. Na2CO3 (70 mL)
4. dry with materialdried (Na2SO4)
5. filtrationfiltered
6. customevaporated
7. customThe residue is purified by MPLC