反应详情

温度

55 °C

4-Benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylic acid (56.0 g) was dissolved in N,N-dimethylformamide (1000 mL). To this solution, sodium bicarbonate (46.6 g) and then ethyl iodide (22.2 mL) were added and the mixture was stirred at 50 to 60° C. for 5 hours. Subsequently, additional sodium bicarbonate (46.6 g) and ethyl iodide (22.2 mL) were added and the mixture was stirred for additional 3 hours. The insoluble materials in the mixture were filtered and the filtrate was concentrated under reduced pressure. The residue was dissolved in ethyl acetate (700 mL) and the solution was washed with water, dried over anhydrous sodium sulfate, and dried under reduced pressure. The resulting residue was purified by silica gel column chromatography (eluant: hexane:ethyl acetate=2:1→ethyl acetate) to give ethyl 4-benzyloxycarbonylaminobicyclo[2.2.2]octane-1-carboxylate (56.8 g).

1. stirringthe mixture was stirred for additional 3 hours
2. filtrationThe insoluble materials in the mixture were filtered
3. concentrationthe filtrate was concentrated under reduced pressure
4. dissolutionThe residue was dissolved in ethyl acetate (700 mL)
5. washthe solution was washed with water
6. dry with materialdried over anhydrous sodium sulfate
7. customdried under reduced pressure
8. customThe resulting residue was purified by silica gel column chromatography (eluant: hexane:ethyl acetate=2:1→ethyl acetate)