Hydrochloric Acid → HCID 22730764, compound

HRID 2356016Notes

Reaction equation

HRID 2356016 reaction equation
[CH3:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]3[CH:20]=[CH:19][C:14]([C:15]([O:17]C)=[O:16])=[CH:13][CH:12]=3)=[CH:7][C:5]=2[N:6]=1.[Li+].[OH-].O.Cl>C1COCC1.CO>[CH3:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][C:8]([C:11]3[CH:20]=[CH:19][C:14]([C:15]([OH:17])=[O:16])=[CH:13][CH:12]=3)=[CH:7][C:5]=2[N:6]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 22730885Methyl 4-(2-methyl-1,3-benzoxazol-5-yl)benzoate

Product 1

HCID 22730764HCID 22730764, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 8028TetrahydrofuranSolvent

Procedure

A room temperature solution of Example 54A (80 mg, 3.0 mmol) and LiOH (630 mg, 15.0 mmol) in a mixture of THF (15 mL), water (4 mL), and methanol (4 mL) was stirred for 1 hour, poured into 1M HCl, and extracted with ethyl acetate. The combined extracts were washed with brine, dried (Na2SO4), filtered, and concentrated to provide the desired product of sufficient purity for subsequent use.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe combined extracts were washed with brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. concentrationconcentrated

Sources & evidence

ORD record
ord-3e1f5b382a334702acff95bb406fb058
Source dataset
uspto-grants-2010_07
Patent number
US07754886B2

Reaction notes

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