反应详情

温度

80 °C

A mixture of 2-ethyl-6-fluoro-1-phenyl-3-piperidin-4-yl-1H-indole (70 mg, TFA salt), 1-(3-Bromo-propylsulfanyl)-4-fluoro-benzene (44 mg), potassium iodide (5 mg) and potassium carbonate (55 mg) in DMF (3 ml) is heated at 80° C. for 3 h, and allowed to cool to r.t. overnight. Ethyl acetate (50 ml) and water (25 ml) are added and the organic phase is washed with water, dried and concentrated in vacuo. The crude product is purified by flash chromatography (98:2 CH2Cl2:MeOH) to give 50 mg pure product (64%) as brown solid.

1. temperatureto cool to r.t. overnight
2. washthe organic phase is washed with water
3. customdried
4. concentrationconcentrated in vacuo
5. customThe crude product is purified by flash chromatography (98:2 CH2Cl2:MeOH)