Water → 1-Methyl 2,6-dichloro-1,4-benzenedicarboxylate

HRID 2356995Notes

Reaction equation

HRID 2356995 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([C:11]([O:13]C)=[O:12])[CH:8]=[C:7]([Cl:15])[C:3]=1[C:4]([OH:6])=[O:5].[OH-].[Na+].O.O1CCC[CH2:20]1>Cl.C(OCC)(=O)C>[CH3:20][O:6][C:4](=[O:5])[C:3]1[C:2]([Cl:1])=[CH:10][C:9]([C:11]([OH:13])=[O:12])=[CH:8][C:7]=1[Cl:15]

Participants

7

Reactant 4

HCID 962WaterHCID 8028TetrahydrofuranHCID 14798Sodium HydroxideHCID 684593252,6-Dichloro-4-(methoxycarbonyl)benzoic acid

Product 1

HCID 186730161-Methyl 2,6-dichloro-1,4-benzenedicarboxylate

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

The mixture of 560 mg of 2,6-dichloro-4-methoxycarbonyl benzoic acid, 85 mg of sodium hydroxide, 5 ml of water and 5 ml of tetrahydrofuran was stirred for 1 hour. The mixture was diluted with 1N hydrochloric acid and treated by an ordinary method using ethyl acetate as an extractant to obtain the title compound.

Workup

  1. additiontreated by an ordinary method

Sources & evidence

ORD record
ord-04fb529a1f6d4feda0e453ccaadbedfd
Source dataset
uspto-grants-2010_07
Patent number
US07759388B2

Reaction notes

Loading…