Hydrochloric Acid → HCID 68732684, compound

HRID 2358296Notes

Reaction equation

HRID 2358296 reaction equation
C(OC(=O)NC1CCNC([CH2:14][N:15]2[C:24]([C:25]#[N:26])=[C:23]([C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=3)[C:22]3[C:17](=[CH:18][CH:19]=[C:20]([O:33][CH3:34])[CH:21]=3)[C:16]2=[O:35])C1)(C)(C)C.[ClH:37]>C(OCC)(=O)C>[ClH:37].[C:25]([C:24]1[N:15]([CH2:14][CH:22]2[CH2:23][CH2:24][NH:15][CH2:16][CH2:17]2)[C:16](=[O:35])[C:17]2[C:22]([C:23]=1[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)=[CH:21][C:20]([O:33][CH3:34])=[CH:19][CH:18]=2)#[N:26]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68718774HCID 68718774, compound

Product 1

HCID 68732684HCID 68732684, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

A solution of 57 (200 mg, 0.423 mmol) in ethyl acetate (100 mL) was cooled in an ice bath and treated with hydrogen chloride gas for 10 min. The resulting solution was stirred 1.5 h and then warmed to room temperature. Evaporation of the solvent in vacuo gave 58 as a white solid.

Workup

  1. customEvaporation of the solvent in vacuo

Sources & evidence

ORD record
ord-07940e76388f43d29e52f4c5ef97a682
Source dataset
uspto-grants-2010_07
Patent number
US07763614B2

Reaction notes

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