Potassium Carbonate → HCID 58828539, compound

HRID 2358300Notes

Reaction equation

HRID 2358300 reaction equation
[CH:1]1([N:4]2[C:13]([C:14]#[N:15])=[C:12]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=3)[C:11]3[C:6](=[CH:7][CH:8]=[C:9]([OH:23])[CH:10]=3)[C:5]2=[O:24])[CH2:3][CH2:2]1.C([O-])([O-])=O.[K+].[K+].[CH2:31]([O:38][CH2:39][CH2:40]Br)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1>CN(C=O)C>[CH2:31]([O:38][CH2:39][CH2:40][O:23][C:9]1[CH:10]=[C:11]2[C:6](=[CH:7][CH:8]=1)[C:5](=[O:24])[N:4]([CH:1]1[CH2:2][CH2:3]1)[C:13]([C:14]#[N:15])=[C:12]2[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([F:22])[CH:17]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 73833Benzene, ((2-bromoethoxy)methyl)-HCID 11393032HCID 11393032, compound

Product 1

HCID 58828539HCID 58828539, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

A mixture of the phenol 62 (80 mg, 0.25 mmol), K2CO3 (104 mg, 0.75 mmol) and benzyloxyethyl bromide (64 mg, 0.3 mmol) in DMF (3 mL) was heated in a microwave reactor at 120° C. for 15 min. The mixture was filtered and directly purified using an automated high pressure chromatography unit.

Workup

  1. filtrationThe mixture was filtered
  2. customdirectly purified

Sources & evidence

ORD record
ord-2dadb4b3f10e49689798af3c75a5858a
Source dataset
uspto-grants-2010_07
Patent number
US07763614B2

Reaction notes

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