Potassium Carbonate → HCID 68455948, compound

HRID 2358401Notes

Reaction equation

HRID 2358401 reaction equation
[CH3:1][O:2][C:3](=[O:17])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])=[CH:8][C:7]=1[OH:16].[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH:28](OS(C)(=O)=O)[CH2:27][CH2:26]1)=[O:24])([CH3:21])([CH3:20])[CH3:19].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[C:18]([O:22][C:23]([N:25]1[CH2:30][CH2:29][CH:28]([O:16][C:7]2[CH:8]=[C:9]([C:12]([CH3:13])([CH3:14])[CH3:15])[CH:10]=[CH:11][C:6]=2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[O:17])[CH2:27][CH2:26]1)=[O:24])([CH3:21])([CH3:19])[CH3:20]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 41848691-(tert-Butoxycarbonyl)-4-(methanesulfonyloxy)piperidineHCID 68454676HCID 68454676, compound

Product 1

HCID 68455948HCID 68455948, compoundYield 104%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

3-(4-tert-Butyl-2-hydroxyphenyl)acrylic acid methyl ester (24.7 mg, 0.105 mmole), 4-methanesulfonyloxypiperidine-1-carboxylic acid tert-butyl ester (58.7 mg, 0.210 mmol), potassium carbonate (43.7 mg, 0.316 mmol) was added in DMF. The reaction mixture was stirred overnight. The reaction mixture was purified according to step 1 of Example 30 to give solid (45.6 mg, 100%).

Workup

  1. customThe reaction mixture was purified

Sources & evidence

ORD record
ord-478a07692ea442508a553ca79a385c59
Source dataset
uspto-grants-2010_07
Patent number
US07763657B2

Reaction notes

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