反应详情

Phenyl acetic acid (489 mg, 3.59 mmol) and 4-t-butylbenzaldehyde (573 mmg, 3.53 mmol), TEA (5 ml) and acetic anhydride (5 ml) were added in round flask. A reaction mixture was heated and stirred overnight. The reaction mixture was poured into 5% HCl aqueous solution (30 ml). A aqueous solution was extracted with MC (30 ml×3). A combined organic layer was dried over MgSO4 and then concentrated in vacuo. The crude residue was column-chromatographed (hexane/ethylacetate=4/1) to yield a white solid (382 mg, 73%)

1. temperatureA reaction mixture was heated
2. extractionA aqueous solution was extracted with MC (30 ml×3)
3. dry with materialA combined organic layer was dried over MgSO4
4. concentrationconcentrated in vacuo
5. customThe crude residue was column-chromatographed (hexane/ethylacetate=4/1)