Isobutyryl chloride → N-[2-(Furan-2-yl)-2-oxoethyl]-2-methylpropanamide

HRID 235901Notes

Reaction equation

Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]([CH2:9][NH2:10])=[O:8].C(=O)(O)[O-].[Na+].[C:16](Cl)(=[O:20])[CH:17]([CH3:19])[CH3:18]>>[C:16]([NH:10][CH2:9][C:7]([C:3]1[O:2][CH:6]=[CH:5][CH:4]=1)=[O:8])(=[O:20])[CH:17]([CH3:19])[CH3:18]

Participants

Reactant 3

HCID 62325Isobutyryl chloride

HCID 516892Sodium Bicarbonate

HCID 132261382-Amino-1-(furan-2-yl)ethan-1-one--hydrogen chloride (1/1)

Product 1

HCID 13773127N-[2-(Furan-2-yl)-2-oxoethyl]-2-methylpropanamideYield 67.3%

Procedure

16.0 g of (2-furylcarbonyl)methylamine hydrochloride, 20.5 g of sodium bicarbonate and 11.4 g of isobutyryl chloride are treated in the same manner as described in Preparation 1-(1). 13.0 g of N-isobutyryl-(2-furylcarbonyl)methylamine are thereby obtained. Yield: 67.0%

Workup

customas described in Preparation 1-(1)

Sources & evidence

ORD record: ord-2d53a3c51f7145179e7411d1a9b956a7
Source dataset: uspto-grants-1987_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04642313

Reaction notes

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