Benzyl Alcohol → HCID 59321323, compound

HRID 2360425Notes

Reaction equation

HRID 2360425 reaction equation
C(=O)([O-])[O-].[K+].[K+].[CH2:7]([OH:14])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[F:15][C:16]1[CH:21]=[C:20](F)[CH:19]=[C:18]([F:23])[C:17]=1[N+:24]([O-:26])=[O:25].CCOC(C)=O.O>CN(C=O)C>[CH2:7]([O:14][C:20]1[CH:21]=[C:16]([F:15])[C:17]([N+:24]([O-:26])=[O:25])=[C:18]([F:23])[CH:19]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 4

HCID 244Benzyl AlcoholHCID 11430Potassium CarbonateHCID 675671,3,5-Trifluoro-2-nitrobenzeneHCID 22728543Water ethylacetate

Product 1

HCID 59321323HCID 59321323, compoundYield 70.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Potassium carbonate (544 mg, 3.94 mmol) and benzyl alcohol (0.3 ml, 2.8 mmol) were added to a solution of 2,4,6-trifluoronitrobenzene (500 mg, 2.8 mmol) in DMF (5 ml). This mixture was stirred at RT overnight. Work up (EtOAc/H2O) afforded the title compound (521 mg) as a yellow liquid which was used in the next step without fuRTher purification.

Sources & evidence

ORD record
ord-4d11d62618d148f7ba6ad03a4ba6058d
Source dataset
uspto-grants-2014_04
Patent number
US08686048B2

Reaction notes

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