Sodium Bicarbonate → HCID 59856627, compound

HRID 2360483Notes

Reaction equation

HRID 2360483 reaction equation
[C:1]([C:5]1[CH:6]=[C:7]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[C:8]([O:38][CH3:39])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:37])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:29][CH2:28][N:27](C(OC(C)(C)C)=O)[CH2:26][CH2:25]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:3])[CH3:2].C(=O)([O-])O.[Na+]>Cl.C(O)(C)C>[C:1]([C:5]1[CH:6]=[C:7]([NH:40][S:41]([CH3:44])(=[O:43])=[O:42])[C:8]([O:38][CH3:39])=[C:9]([NH:11][C:12]([C:14]2[N:15]([CH3:37])[C:16]3[C:21]([CH:22]=2)=[CH:20][CH:19]=[CH:18][C:17]=3[CH2:23][N:24]2[CH2:25][CH2:26][NH:27][CH2:28][CH2:29]2)=[O:13])[CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

5

Reactant 2

HCID 516892Sodium BicarbonateHCID 11563567HCID 11563567, compound

Product 1

HCID 59856627HCID 59856627, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 3776IsopropanolSolvent

Procedure

1.13 g tert-butyl 4-[2-(5-tert-butyl-3-methanesulphonylamino-2-methoxy-phenylcarbamoyl)-1-methyl-1H-indol-7-ylmethyl]-piperazine-1-carboxylate are dissolved in 20 ml of a 5 M solution of HCl in isopropanol and stirred for 12 hours at ambient temperature. Then the mixture is adjusted to pH 9 with saturated aqueous sodium hydrogen carbonate solution and extracted twice with ethyl acetate. The combined organic phases are dried on magnesium sulphate and the solvent is eliminated in vacuo.

Workup

  1. extractionextracted twice with ethyl acetate
  2. customThe combined organic phases are dried on magnesium sulphate

Sources & evidence

ORD record
ord-279fa87cd84142c4b73ce3ea638588ba
Source dataset
uspto-grants-2014_04
Patent number
US08686022B2

Reaction notes

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