Water → HCID 20217034, compound

HRID 236287Notes

Reaction equation

HRID 236287 reaction equation
C([C:9]1[CH2:20][N:12]2[C:13](=[O:19])[N:14]=[C:15]([O:17][CH3:18])[CH:16]=[C:11]2[N:10]=1)(=O)C1C=CC=CC=1.[H-].[Na+].I[CH2:24][CH3:25].O>CN(C)C=O>[CH2:24]([N:14]1[C:15]([O:17][CH3:18])=[CH:16][C:11]2=[N:10][CH:9]=[CH:20][N:12]2[C:13]1=[O:19])[CH3:25]

Participants

6

Reactant 4

HCID 962WaterHCID 6340IodoethaneHCID 24758Sodium hydrideHCID 70381747HCID 70381747, compound

Product 1

HCID 20217034HCID 20217034, compoundYield 29.1%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A stirred solution of 11 g of 2-benzoyl-7-methoxyimi-dazo[1,2-c]pyrimidin-5-one in 33 ml of dry dimethylformamide was treated with 1.27 g of 80% of sodium hydride and was stirred for another hour. 8 g of iodoethane were added dropwise over 10 minutes and stirring was continued for two hours after which the mixture was poured into iced water. The mixture was filtered to obtain 2.3 g of 6-ethyl-7-methoxyimidazo[1,2-c]pyrimidin-5-one as a yellow crystalline solid melting at 159°-60° C.

Workup

  1. stirringstirring
  2. filtrationThe mixture was filtered

Sources & evidence

ORD record
ord-2e47507b46374b8c8b871a3aeba34e11
Source dataset
uspto-grants-1987_02
Patent number
US04643999

Reaction notes

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