反应详情

温度

120 °C

A mixture of 3-(ethylamino)-5-(pyridin-4-yl)thiophene-2-carboxamide (0.100 g, 0.400 mmol), 3-pentanone (3.0 mL), p-toluenesulfonic acid monohydrate (0.0095 g, 0.050 mmol) and acetic acid (3.0 mL) was stirred for 1 h at 120° C. in a sealed tube. Then, this mixture was stirred for 2 h at 150° C. and stirring was continued for 2 days at 110° C. in a sealed tube. The mixture was poured into sat. aqueous sodium hydrogen carbonate (150 mL). Extraction with ethyl acetate (100 mL), drying over magnesium sulfate, filtration and concentration at reduced pressure gave an oil. This oil was purified by column chromatography (Combiflash, 40 g silica gel, dichloromethane to ethyl acetate), then recrystallized from ethyl acetate, and the precipitate was collected by filtration to afford the title compound (0.0194 g, 12%) as a yellow solid:

1. stirringThen, this mixture was stirred for 2 h at 150° C.
2. stirringstirring
3. waitwas continued for 2 days at 110° C. in a sealed tube
4. extractionExtraction with ethyl acetate (100 mL)
5. dry with materialdrying over magnesium sulfate, filtration and concentration at reduced pressure
6. customgave an oil
7. customThis oil was purified by column chromatography (Combiflash, 40 g silica gel, dichloromethane to ethyl acetate)
8. customrecrystallized from ethyl acetate
9. filtrationthe precipitate was collected by filtration