3-Isopropoxypropylamine → 3-(3-Isopropoxypropylsulfamoyl)benzoic acid

HRID 2365545Notes

Reaction equation

HRID 2365545 reaction equation
[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH2:8])([CH3:3])[CH3:2].C(N(CC)C(C)C)(C)C.C[C:19]1[C:27]([S:28](Cl)(=[O:30])=[O:29])=[CH:26][CH:25]=[CH:24][C:20]=1[C:21]([OH:23])=[O:22]>C1COCC1>[CH:1]([O:4][CH2:5][CH2:6][CH2:7][NH:8][S:28]([C:27]1[CH:19]=[C:20]([CH:24]=[CH:25][CH:26]=1)[C:21]([OH:23])=[O:22])(=[O:30])=[O:29])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 761943-IsopropoxypropylamineHCID 81531DiisopropylethylamineHCID 543955313-(Chlorosulfonyl)-2-methylbenzoic acid

Product 1

HCID 670865933-(3-Isopropoxypropylsulfamoyl)benzoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

3-Isopropoxypropylamine (1.1 eq.) is dissolved in THF with stirring at room temperature. N,N-diisopropylethylamine (1 eq.) is added followed by methyl 3-(chlorosulfonyl)benzoic acid (1 eq.). The reaction mixture is stirred at room temperature for 2 hours before the solvent is evaporated in vacuo to yield the crude titled product.

Workup

  1. stirringThe reaction mixture is stirred at room temperature for 2 hours before the solvent
  2. customis evaporated in vacuo

Sources & evidence

ORD record
ord-32e74f3be3624f049b9eaa4912f5f53f
Source dataset
uspto-grants-2014_04
Patent number
US08697687B2

Reaction notes

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