Potassium Carbonate → HCID 25176118, compound

HRID 2366013Notes

Reaction equation

HRID 2366013 reaction equation
Br[CH2:2][CH:3]1[O:8][C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4]1.[NH:13]1[CH2:18][CH2:17][CH2:16][CH:15]([OH:19])[CH2:14]1.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[O:8]1[C:7]2[CH:9]=[CH:10][CH:11]=[CH:12][C:6]=2[O:5][CH2:4][CH:3]1[CH2:2][N:13]1[CH2:18][CH2:17][CH2:16][CH:15]([OH:19])[CH2:14]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 232933-HydroxypiperidineHCID 983332-Bromomethyl-1,4-benzodioxane

Product 1

HCID 25176118HCID 25176118, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
153 °C

Procedure

A mixture of 2-bromomethyl-2,3-dihydrobenzo[1,4]dioxine (2.26 g, 9.88 mmol), piperidin-3-ol (1.0 g, 9.88 mmol) and K2CO3 (6.8 g, 49.43 mmol) in DMF (30 ml) was heated under microwaves at 153° C. for 120 min to give the crude title compound after the usual work-up. The product was purified by column chromatography (DCM/MeOH, 98:2).

Sources & evidence

ORD record
ord-e171c9faa9d34541bcaacc1d3d3a3ed2
Source dataset
uspto-grants-2014_04
Patent number
US08697723B2

Reaction notes

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