Hydrochloric Acid → HCID 69261508, compound

HRID 2366464Notes

Reaction equation

HRID 2366464 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:5]=[CH:6][C:7]=1[C:8]([O:10]C)=[O:9].O.[OH-].[Li+].CO.Cl>C1COCC1.O>[C:8]([C:7]1[CH:6]=[CH:5][C:4]([CH:12]2[CH2:16][CH2:15][CH2:14][N:13]2[C:17]([O:19][C:20]([CH3:22])([CH3:21])[CH3:23])=[O:18])=[CH:3][C:2]=1[F:1])([OH:10])=[O:9]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 168937Lithium hydroxide, monohydrateHCID 46205448HCID 46205448, compound

Product 1

HCID 69261508HCID 69261508, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of EXAMPLE 50C (5.5 g) and lithium hydroxide monohydrate (1.43 g) in THF (50 mL) and water (50 mL) was titrated with methanol until transparent, stirred at ambient temperature for 2 hours, acidified to pH 2 with 2M HCl, concentrated to about 40 mL and filtered.

Workup

  1. concentrationconcentrated to about 40 mL
  2. filtrationfiltered

Sources & evidence

ORD record
ord-67ce50f458bb45fa89d7ea97faa0184f
Source dataset
uspto-grants-2014_04
Patent number
US08697736B2

Reaction notes

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