Propylamine → HCID 69506709, compound

HRID 2366628Notes

Reaction equation

HRID 2366628 reaction equation
[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][C:19](OCC)=[O:20])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3].[CH2:24]([NH2:27])[CH2:25][CH3:26]>C1COCC1>[CH2:1]([C:4]1[N:5]([CH2:17][CH2:18][C:19]([NH:27][CH2:24][CH2:25][CH3:26])=[O:20])[C:6]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[CH:8][C:7]=2[N:16]=1)[CH2:2][CH3:3]

Participants

4

Reactant 2

HCID 7852PropylamineHCID 57447034HCID 57447034, compound

Product 1

HCID 69506709HCID 69506709, compoundYield 97.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)propanoate (3.45 g, 11.1 mmol), n-propylamine (9.1 mL, 110 mmol), and THF (5 mL) was heated at 80° C. for two days in a high-pressure vessel, allowed to cool to ambient temperature, and concentrated under reduced pressure to provide 3.5 g of 3-(2-propyl-1H-imidazo[4,5-c]quinolin-1-yl)-N-propylpropanamide.

Workup

  1. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-aae4eb95a6464f9aad5e002f5cdb416c
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

Loading…