Methylamine → HCID 57447042, compound

HRID 2366644Notes

Reaction equation

HRID 2366644 reaction equation
[N:1]1([CH2:14][CH2:15][C:16]([O:18]CC)=O)[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1.C1COCC1.[CH3:26][NH2:27]>O>[N:1]1([CH2:14][CH2:15][C:16]([NH:27][CH3:26])=[O:18])[C:13]2[C:12]3[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=3[N:6]=[CH:5][C:4]=2[N:3]=[CH:2]1

Participants

5

Reactant 3

HCID 6329MethylamineHCID 8028TetrahydrofuranHCID 57447041HCID 57447041, compound

Product 1

HCID 57447042HCID 57447042, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of ethyl 3-(1H-imidazo[4,5-c]quinolin-1-yl)propanoate (4.70 g, 17.5 mmol), THF (5 mL), and methylamine (available as a 40% solution in water, 10 mL) was sealed in a high-pressure vessel, stirred at 100° C. overnight, and concentrated under reduced pressure to provide 4.4 g of 3-(1H-imidazo[4,5-c]quinolin-1-yl)-N-methylpropanamide.

Workup

  1. customwas sealed in a high-pressure vessel
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-5309d81d2e4348b9af1ffe235a4a8685
Source dataset
uspto-grants-2014_04
Patent number
US08697873B2

Reaction notes

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