Hydrogen Bromide → (6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide

HRID 2366818Notes

Reaction equation

HRID 2366818 reaction equation
C(N(CC)[C:4]([CH:6]1[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]1)=[O:5])C.[Br:15][C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([Br:22])[N:17]=1.Br>>[BrH:15].[Br:22][C:18]1[N:17]=[C:16]([C:4]([CH:6]2[CH2:11][CH2:10][N:9]([CH3:12])[CH2:8][CH2:7]2)=[O:5])[CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 3

HCID 260Hydrogen BromideHCID 122742,6-DibromopyridineHCID 412858N,N-DIETHYL-1-METHYL-PIPERIDINE-4-CARBOXAMIDE

Product 1

HCID 86679073(6-Bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide

Procedure

reacting N,N-diethyl-1-methylpiperidine-4-carboxamide with a solution of 2,6-dibromopyridine and Grignard reagent followed by hydrobromic acid to yield (6-bromopyridin-2-yl)(1-methylpiperidin-4-yl)methanone hydrobromide;

Sources & evidence

ORD record
ord-53e29b5148414edc8c5585f4e59b8749
Source dataset
uspto-grants-2014_04
Patent number
US08697876B2

Reaction notes

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