Potassium Carbonate → 4-(9H-Carbazol-3-yl)dibenzofuran

HRID 2367661Notes

Reaction equation

HRID 2367661 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][CH:10]=[CH:9][CH:8]=3.[CH:15]1[C:23]2[C:22]3[CH:24]=[CH:25][CH:26]=[CH:27][C:21]=3[O:20][C:19]=2[C:18](B(O)O)=[CH:17][CH:16]=1.C1(C)C=CC=CC=1P(C1C=CC=CC=1C)C1C=CC=CC=1C.C(=O)([O-])[O-].[K+].[K+]>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.C(O)C.C1(C)C=CC=CC=1>[CH:4]1[C:5]2[NH:6][C:7]3[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=3)[C:13]=2[CH:14]=[C:2]([C:27]2[C:21]3[O:20][C:19]4[CH:18]=[CH:17][CH:16]=[CH:15][C:23]=4[C:22]=3[CH:24]=[CH:25][CH:26]=2)[CH:3]=1

Participants

8

Reactant 4

HCID 11430Potassium CarbonateHCID 80271Tri-o-tolylphosphineHCID 2524463-BromocarbazoleHCID 2734328Dibenzofuran-4-boronic acid

Product 1

HCID 666918774-(9H-Carbazol-3-yl)dibenzofuranYield 85%

Reagents, catalysts & solvents 3

HCID 167845palladium(II) acetateCatalystHCID 702EthanolSolventHCID 1140TolueneSolvent

Conditions

Temperature
80 °C

Procedure

Into a 200 mL three-neck flask were placed 2.0 g (8.1 mmol) of 3-bromocarbazole, 1.7 g (8.1 mmol) of dibenzofuran-4-boronic acid, and 150 mg (0.5 mol) of tri(ortho-tolyl)phosphine, and the air in the flask was replaced with nitrogen. To this mixture were added 20 mL of toluene, 20 mL of ethanol, and 15 mL (0.2 mol) of an aqueous solution of potassium carbonate (2.0 mol/L). In the flask, the mixture was degassed by being stirred under reduced pressure. After 23 mg (0.10 mmol) of palladium(II) acetate was added to this mixture, the mixture was refluxed at 80° C. After the reflux, the mixture was cooled to room temperature, and then the obtained solid was collected by suction filtration. The collected solid was dissolved in 100 mL of toluene, and this solution was filtered through Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), and alumina. The solid obtained by concentration of the obtained filtrate was recrystallized from toluene/hexane, so that 2.3 g of a white solid was obtained in 85% yield. The synthesis scheme of Step 1 is illustrated in the formula (a-2).

Workup

  1. customInto a 200 mL three-neck flask were placed
  2. customIn the flask, the mixture was degassed
  3. temperatureAfter the reflux, the mixture was cooled to room temperature
  4. filtrationthe obtained solid was collected by suction filtration
  5. dissolutionThe collected solid was dissolved in 100 mL of toluene
  6. filtrationthis solution was filtered through Celite (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855), Florisil (produced by Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), and alumina
  7. customThe solid obtained by concentration of the obtained filtrate
  8. customwas recrystallized from toluene/hexane, so that 2.3 g of a white solid
  9. customwas obtained in 85% yield
  10. customThe synthesis scheme of Step 1

Sources & evidence

ORD record
ord-5e16a24ca1fc413694a2ec73c0dadc0f
Source dataset
uspto-grants-2014_04
Patent number
US08697885B2

Reaction notes

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