Hydrochloric Acid → HCID 57513606, compound

HRID 2368399Notes

Reaction equation

HRID 2368399 reaction equation
C(OC(=O)[NH:7][C:8]([C:11](=[O:31])[NH:12][C:13]1[S:14][C:15]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)([CH3:10])[CH3:9])(C)(C)C.Cl>CCOC(C)=O>[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([NH:12][C:13]1[S:14][C:15]([CH2:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)=[O:31]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57513605HCID 57513605, compound

Product 1

HCID 57513606HCID 57513606, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[1-(5-Benzyl-4-phenyl-thiazol-2-ylcarbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester (6.4 g) was stirred overnight in freshly prepared HCl (g)/EtOAc solution (150 mL). Evaporation of the solvent gave the title compound as the hydrochloride salt. 1H NMR (400 MHz, DMSO-D6) δ 1.62 (s, 6H) 4.24 (s, 2H) 7.16-7.25 (m, 3H) 7.30 (d, J=7.58 Hz, 2H) 7.37 (s, 1H) 7.41-7.47 (m, 2H) 7.58-7.63 (m, 2H) 8.64 (s, 3H). m/z 352.1 (MH+).

Workup

  1. customEvaporation of the solvent

Sources & evidence

ORD record
ord-8cd0e99bed11446ba366508f30e380fc
Source dataset
uspto-grants-2014_04
Patent number
US08703761B2

Reaction notes

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